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As usual, Wikipedia has a nice explanation of what defective pixels (including dead pixels) are.

The title of the image ("I'd press on them to try to unstick them, but I can't reach. Can we try cycling day and night really fast?") also refers to how you usually try to get rid of them if your LCD screen has some of them - either soft mechanical pressure or repeated cycles from "on" to "off" and vice versa.

However, the title IMHO also clearly shows that the author does not refer to an artificial viewing device with respect to those visual errors. Regarding the "stars" idea: I am not sure - if you have a close look at the comic strip you can actually see three "dead" pixels arranged as a triangle, which are colored red, pink and green - not white, yellow or blue as you'd expect for a star.